Japanese
NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE
Department of Intractable Diseases
Director  Dr. Yukihito Ishizaka

ACADEMIC FORUM
Poster Display Booth:  A-10
Presentation Date: May 9 (Thur)  16:10 ~ 16:40        Presentation Venue: ACA-6
 
Title: Production of virus-free iPS cells by a novel cell penetrating peptide
 
Abstract: We identified a novel cell penetrating peptide (NTP: nuelear trafficking peptide), and applied it on production of virus-free iPS cells from mouse embryonic fibroblasts. We discuss possible collaboration with a company
Outlines/Features of Research
NTP is superior to known cell-penetrating peptides such as Tat-derived peptide and R11. By combination with protease and endonuclease, NTP enables us to process proteins within cells of interest and genome-manipulation. In addition to virus-free production of iPS cells, it is possible to apply NTP on a variety of cellular transformation just by proteins.
Expected Applications
Regenerative medicine
Genome manipulation by proteins
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Profile

Main Research Subjects: Clinical application of NTP, Retrotransposition, Development of angiotensin converting enzyme 2 activators.
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