NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION Laboratory of Stem Cell Cultures Postdoctoral fellow Dr. Masaki Kinehara
ACADEMIC FORUM Poster Display Booth: G-13
May 8 (Wed) 14:50 ~ 15:20 Presentation Venue: ACA-8
Screening for compounds using hiPS cells and a chemically defined serum-free culture
Using hiPS cells and a growth factor defined serum-free medium hESF9, chemical library were screened. We found a molecule which regulates undifferentiated state of hES/iPS cells.
Outlines/Features of Research
The self-renewal of human pluripotent stem (hPS) cells has been reported to be supported by FGF-2. However, downstream signaling of FGF-2 has not yet been clearly understood. We screened a kinase inhibitor library to understand FGF-2-related molecular mechanisms regulating self-renewal of hPS cells, and found that FGF-2-induced PKC regulates the hPS cell self-renewal and differentiation.
This study found a mechanism to control the undifferentiated state of human ES/iPS cells. This finding may contribute to the culture method for large-scale production of the human ES/iPS cells.
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2009 Graduate School of Science and Technology, Kobe University,Awarded the degree of PhD (Doctor of Agriculture). 2009-Present Postdoctoral fellow, National Institute of Biomedical Innovation. Main Reserch subject: Study on mechanism of human ES/iPS cell self-renewal and differentiation